Biologically plausible.
Concerning the possible effects of iron and molybdenumon gout:
I am NOT saying that these are necessarily proven oreven that there exists substantial evidence wherein itwould be sensible to rely on the supposed connectionactually existing.
However, females who menstruate and therefore loseiron, do not get gout. Females who cease menstruationare susceptible to gout. The crystals that precipitatein gout are sodium-urate-iron crystals. This makes therole of iron biologically plausible, but not proven.
Concerning Molybdenum:
It is extremely hard for a human to acquire too muchof this mineral as it is present in the normal diet inonly minute amounts. However, when sheep or cattleingest excessive amounts, they do develop a conditionthat bears similarities to gout. It has been suggestedthat Mo may inhibit certain enzymes at “high”concentrations and since people are so rarely testedfor Mo, no one would know that they have a high Molevel. Mo and S each bind to Cu in the kidneys andimpair kidney function leading to increased uric acidlevels. It seems ‘reasonable’ to consider Mo levels.I’m not saying it should be a primary consideration.
Concerning vitamin D:
It is possible that uric acid directly decreases serumlevels of Vitamin D by inhibiting 1 alpha-hydroxylaseaction. This is not proven, but again there areindications and it is biologically plausible. Since asupplement of Vitamin D would be cheap, have littlerisk and would not require an Rx, I thought it wouldbe a good issue to bring up
Terrance Molock on July 23rd, 2007
Females are no different than males..in that..their uric acidlevels rise..(from internal situations)they then become moresucesptible to gout.
Julius Lucca on July 24th, 2007
Interesting… are there no further info on this or some on-goingresearch?
Sabina Shamel on July 24th, 2007
The crystals that form in gout are chemically pure monosodium urate.There is no iron within the crystal structure. Within the pH rangesof blood, the di-valent ionized state of uric acid does not exist.
It is possible that a seed crystal for initiating the crystallizationprocess might contain iron but the majority of the deposition thatoccures in your toes and feet is absolutely pure, crystalline, monosodium urate.
Your statement about women and menstration makes about as much senseas my assertion that the color green might bring on gout.Let’s see, women menstrate so they have lower red blood cell count,mmm they have higher estrogen, they have ovaries, they have mmm letssee, longer hair, perhaps longer hair will protect you…
Look, I can speculate with anyone on what might be the cause of goutbut, if you have gout, you should be taking allopurinol if your bodycan tolerate it. End the gout and your interest in esoteric rootcauses will wane dramatically.
Sabina Shamel on July 25th, 2007
A much more important question still lingers, as far as myliterature search goes, and that is the role calcium plays in gout.
Severe attacks, particularly second and third attacks that linger fora long while, and cause intense main, end up literally leachingcalcium from the joint, in and around where the gout attack wascentered.
You actually lose calcium from your bones in the area where your goutattack was.
Now the question that I have asked and which I do not know the answerto is this, Should a person with gout take calcium every day and ifso what amount. Physicians will perscribe calcium for women but it isto fight off osteoperosis. Should I be consuming calcium every day ornot?