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	<title>Comments on: Trophi and crystaline monosodium urate</title>
	<link>http://www.goutdietblog.com/archives/32</link>
	<description>Diet for gout</description>
	<pubDate>Tue, 06 Jan 2009 14:47:25 +0000</pubDate>
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		<title>By: Sabina Shamel</title>
		<link>http://www.goutdietblog.com/archives/32#comment-33</link>
		<author>Sabina Shamel</author>
		<pubDate>Sun, 23 Sep 2007 14:21:21 +0000</pubDate>
		<guid>http://www.goutdietblog.com/archives/32#comment-33</guid>
					<description>Based on the overwhelming reply stream I judge that the interest inthis subject is so high that I'll continue with my wesson oil andwater analogy.

Uric acid is not completely soluble in all proportions in wesson oilnor is mono-sodium urate completely soluble in all proportions inwater. Literally your blood is an aqueous system, that is, it is awater based medium with the salinity, the salt content, of sea water.

So just for fun lets take wesson oil that is saturated with uric acidand place it in contact with water that is saturated with sodiumacetate and shake the system and lat it stand for a while. What willhappen.

The sodium acatate will react with some of the uric acid in thewesson oil and it will neutralize it which will form sodium urate andacetic acid.

Now, lets push the limits of solubility of sodium urate and uric acidin both the water and the oil and put in more sodium urate than thewater can hold and more uric acid than the wesson oil can hold.

What will we get.

Of course this is a simple minded explanation but the uiric acid willform a semi solid goo of uric acid. The water will contain extra monosodium urate and those crystals will be deposited all around thewater layer. If the system is shaken and mixed, as in what you dowhan you walk, there will probably be some urate crystals that floatinto the oil layer and you will probably get some urate crystalsphysically imbedded in the uric acid goo just because both are solid,or semi-solid. The semi-solid goo stuff is the stuff of trophi andthe crystals are the monosodium urate that percipitate out in yourtoe and create the inflamation reaction that we all know and love tonot have.

The reason I bring thest things up is that gout is most often-notalways-but very very frequently associated with being over weight andthe mention of the relatin to high blood prewssure has been broughtup and i want to cover both of these things.

First the high blood pressure. Do a search in Goggle on hypertension-(high blood pressure)- and uric acid. What you will find with almostno effort is that in laboratory study after study in rats, dogs,mice, even cats, and clinical studies involving people, there is adirect, measurable, and predictable increase in blood pressureassociated with increasing levels of uric acid.  That's correct. Thehigh urate levels we all run is also causing high blood pressure.Take allo and your blood pressure goes down. Is it the allo thatreduces the blood pressure? Not really but indirectly yes. The allowill stop more urate from forming, the kidneys will slog away as theyalways do at removing the urate, and your blood urate level willfall. Abra ka dabra--so will your blood pressure.

Lets go back to the oil in water and look at a system where there isno solid urate in the water and there is no uric acid in the wessonoil as solid but a system in which both the water and the oil aresaturated with urate and uric acid respectively. This is thesituation most of us lived in just before our gout attacks started.Now, for whatever reason, we either decide to lose weight or we gothrough a period where we are not as hyungry as we were-lets say youfall in love- or lose your lover and lose your apetite and you startliving off of your stored fat -i.e. start to lose weight. What willhappen?The fat layer is essentially saturated with uric acid and you areselectively removing just the fat from the overall bottle. We have amagic membrane that will selectively allow the wesson oil moleculesto pass through but will not allow the uric acid molecules to gothrough. The system that was in equilibrium will now have excess uricacid and it will start to percipitate out. some of the excess uricacid will go into the water solution as urate and monosodium uratecrystals will start to form and in the oil the uric acid goo willstart to form.

It is a relatively simple concept to get your head around althoughthe specifics of how much of the urate can be tolerated and where,where is very complex indeed, the fact remains that, when you startto lose weight your body will remove adipose tissue and the uric acidwill be left behind and therefore the overall concentration of uratein your system will be increased and you will be more succeptable togout attacks.

Anectdotal summary-When I first got gout it was after having injured my knee by falling,nothing to do with gout per se, and I was relatively immobile andgained about 20 pounds. After regaining my left wheel, I went back tothe exercize routine, lost about 12 of the 20 pounds and  and bam-agout attack. My first. I did not associate it with the weight loss.

Gout better after 6 weeks and of course gaining 6 of the 12 pounds Ihad lost. Lose more weight-bam a gout attack. This time longer goutbout and managed to eat my way all the way back to the original 20 Ihad gained. Gout gone and this time thinking about maybe I hadinjured myself to make the gout come back, I exercized but moreslowly and carefully, and at about the same milestone, only 8 poundsfrom  my goal, a really big attack this time-Damn exercize. It iscausing my gout--

Well again it is true but it is indirect. The exercize helps with theweight loss and the weight loss reduces the fat content and that endsup raising the overall uric acid level which percipitates a goutattack.</description>
		<content:encoded><![CDATA[<p>Based on the overwhelming reply stream I judge that the interest inthis subject is so high that I&#8217;ll continue with my wesson oil andwater analogy.</p>
<p>Uric acid is not completely soluble in all proportions in wesson oilnor is mono-sodium urate completely soluble in all proportions inwater. Literally your blood is an aqueous system, that is, it is awater based medium with the salinity, the salt content, of sea water.</p>
<p>So just for fun lets take wesson oil that is saturated with uric acidand place it in contact with water that is saturated with sodiumacetate and shake the system and lat it stand for a while. What willhappen.</p>
<p>The sodium acatate will react with some of the uric acid in thewesson oil and it will neutralize it which will form sodium urate andacetic acid.</p>
<p>Now, lets push the limits of solubility of sodium urate and uric acidin both the water and the oil and put in more sodium urate than thewater can hold and more uric acid than the wesson oil can hold.</p>
<p>What will we get.</p>
<p>Of course this is a simple minded explanation but the uiric acid willform a semi solid goo of uric acid. The water will contain extra monosodium urate and those crystals will be deposited all around thewater layer. If the system is shaken and mixed, as in what you dowhan you walk, there will probably be some urate crystals that floatinto the oil layer and you will probably get some urate crystalsphysically imbedded in the uric acid goo just because both are solid,or semi-solid. The semi-solid goo stuff is the stuff of trophi andthe crystals are the monosodium urate that percipitate out in yourtoe and create the inflamation reaction that we all know and love tonot have.</p>
<p>The reason I bring thest things up is that gout is most often-notalways-but very very frequently associated with being over weight andthe mention of the relatin to high blood prewssure has been broughtup and i want to cover both of these things.</p>
<p>First the high blood pressure. Do a search in Goggle on hypertension-(high blood pressure)- and uric acid. What you will find with almostno effort is that in laboratory study after study in rats, dogs,mice, even cats, and clinical studies involving people, there is adirect, measurable, and predictable increase in blood pressureassociated with increasing levels of uric acid.  That&#8217;s correct. Thehigh urate levels we all run is also causing high blood pressure.Take allo and your blood pressure goes down. Is it the allo thatreduces the blood pressure? Not really but indirectly yes. The allowill stop more urate from forming, the kidneys will slog away as theyalways do at removing the urate, and your blood urate level willfall. Abra ka dabra&#8211;so will your blood pressure.</p>
<p>Lets go back to the oil in water and look at a system where there isno solid urate in the water and there is no uric acid in the wessonoil as solid but a system in which both the water and the oil aresaturated with urate and uric acid respectively. This is thesituation most of us lived in just before our gout attacks started.Now, for whatever reason, we either decide to lose weight or we gothrough a period where we are not as hyungry as we were-lets say youfall in love- or lose your lover and lose your apetite and you startliving off of your stored fat -i.e. start to lose weight. What willhappen?The fat layer is essentially saturated with uric acid and you areselectively removing just the fat from the overall bottle. We have amagic membrane that will selectively allow the wesson oil moleculesto pass through but will not allow the uric acid molecules to gothrough. The system that was in equilibrium will now have excess uricacid and it will start to percipitate out. some of the excess uricacid will go into the water solution as urate and monosodium uratecrystals will start to form and in the oil the uric acid goo willstart to form.</p>
<p>It is a relatively simple concept to get your head around althoughthe specifics of how much of the urate can be tolerated and where,where is very complex indeed, the fact remains that, when you startto lose weight your body will remove adipose tissue and the uric acidwill be left behind and therefore the overall concentration of uratein your system will be increased and you will be more succeptable togout attacks.</p>
<p>Anectdotal summary-When I first got gout it was after having injured my knee by falling,nothing to do with gout per se, and I was relatively immobile andgained about 20 pounds. After regaining my left wheel, I went back tothe exercize routine, lost about 12 of the 20 pounds and  and bam-agout attack. My first. I did not associate it with the weight loss.</p>
<p>Gout better after 6 weeks and of course gaining 6 of the 12 pounds Ihad lost. Lose more weight-bam a gout attack. This time longer goutbout and managed to eat my way all the way back to the original 20 Ihad gained. Gout gone and this time thinking about maybe I hadinjured myself to make the gout come back, I exercized but moreslowly and carefully, and at about the same milestone, only 8 poundsfrom  my goal, a really big attack this time-Damn exercize. It iscausing my gout&#8211;</p>
<p>Well again it is true but it is indirect. The exercize helps with theweight loss and the weight loss reduces the fat content and that endsup raising the overall uric acid level which percipitates a goutattack.</p>
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