I went back over the literature again to confirm that there is noevidence I could find to suggest that allopurinol has any affect onuric acid that has already formed in your body. The mechanism ofaction of allopurinol is to stop the formation of new uric acid.While reading various references, I ran across several very recentreferences that are very important to us.
Earlier medical literature has noted the relationship between goutsufferers and hypertension-(high blood pressure) as well as asimilar correlation with corronary heart disease. Until veryrecently this was thought to be a co-effect of gout, perhaps, it hasbeen suggested, that gout and hypertension are caused by the same, orat least similar, metabolic conditions.
I would suggest that you read at least the first reference I willgive because it is a startling result.
1) http://www.rheumatology.hss.edu/phys/specialReports/uricAcid.asp(July 1, 2003) Theodore R. Fields, MD, FACPInternet Project Director, HSS Division of RheumatologyDirector, HSS Rheumatology Faculty Practice PlanAssociate Professor of Clinical Medicine, Weill Medical College ofCornell UniversityUric Acid and Cardiovascular Disease - Chicken or the Egg? New AnimalData Suggest Possible Pathogenic Role of Urate.
2) Hypertension. 2003 Jun;41(6):1183-90. Johnson RJ, Kang DH, Feig D,Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B,Herrera-Acosta J, Mazzali M:Is there a pathogenetic role for uric Acid in hypertension andcardiovascular and renal disease?
3) Hypertension. 2000 Dec;36(6):1072-8. Verdecchia P, Schillaci G,Reboldi G, Santeusanio F, Porcellati C, Brunetti P.Relation between serum uric acid and risk of cardiovascular diseasein essential hypertension. The PIUMA study.
4) Hypertension. 2001 Nov;38(5):1101-6. Mazzali M, Hughes J, Kim YG,Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ.Elevated uric acid increases blood pressure in the rat by a novelcrystal-independent mechanism.
In order to keep from upsetting anyone as to why I say these things,I will quote from the first reference cited here.
Dr. Fields writes:
“Recent animal studies, however, suggest an independent risk statusof urate.3 Rat data in this study suggested that urate appears to bepathogenic of hypertension, arteriolar wall thickening, andendothelial dysfunction. Mild induced hyperuricemia (using a uricaseinhibitor which does not lead to crystal deposition in the kidney andpreserves renal function) causes hypertension in the rat withinseveral weeks, with stimulation of the renin-angiotensin system andinhibition of NO synthase (and renal injury and fibrosis).
In this model, blood pressure changes were prevented if allopurinolwas given early. Chronically hyperuricemic rats showed salt-sensitivity and thickening of the afferent artery of the glomerulusand tubulointerstitial inflammation and fibrosis - which did notreverse if allopurinol was given late. Hyperuricemia stimulated ratvascular smooth muscle cell proliferation and induced endothelialdysfunction.”
That may be hard to absorb but the bottom line is that when theyartifically induce high urate levels in rats, those rats develop highblood pressure and they develop hardening and thickening of thearteries. More importantly, when those rate were fed allopurinolearly in the test, the hypertension symptoms did not appear. If thesymptoms were allowed to go too long, they were not reversible.
The excess uric acid that we are accumulating from our gout conditionis much more dangerous than just the pain we feel from the attacks.
The high levels of urate in our blood is causing severe andeventually non-reversible cardio-vascular problems.
Based on this finding I plan to get my physician to increase mydosage of allopurinol to a level known to stop urate productionaltogether and then titrate my system back to the optimum level. Thatis, I will move the dosage level down, slowly, based on any badreaction to the drug, based on serum urate levels in the blood andbased on how my gout attacks are progressing.
Some of you have stated your reservations about taking allopurinol,as I did, but allopurinol is indicated for gout sufferers and to myway of looking at it, this is cardio-vascular implication is the mostpersuasive of all the information I have read. I can live a long timewith a pain in my foot, I cannot live very long if my heart and myarterial system are compromized.