Since I am often busy and often irrisponsible, I sometimes forget totake my 300 Mg of Allopurinol. Not often but, it happens and I knowit is a bad thing to allow myself to do.
I got to thinking that when I actually take the allopurinol, that isthe time of day, is probably an important factor in how well it canwork for me.
If you read the article posted at —http://www.rxlist.com/cgi/generic/allopur_cp.htm
and don’t be put off by the big words, you will find that allopurinolreaches its maximum serum levels after about 1.5 hours and itsdecomposition product, oxypurinol-which also inhibits the formationof uric acid, reaches its peak levels at 4 hours. Moving alongthrough the article it says that allopurinol has a half life ofapproximately 2 hours in your system and oxypurinol has a half lifeof about 15 hours. The article says that therefore you have effectiveoxyxanthase protection for 24 hours with a pill once a day—
OK but effective, and “maximum” protection are not the same thing. Ifyou look at what is going on here, if you take your allopurinol at,say 6 am, when you wake up, and you eat your dinner at 6 PM, a likelyset of events for most of us, by the time your food from dinner isbeing processed and the extra purene load is being dumped onto yoursystem- that is assuming that your main meal is in the evening, itwill be about 15 hours after you take your allopurinol if you take itin the morning. Half life means that half of the drug will be gonefrom your system so, after 15 hours there will be essentially noallopurinol in your system-2 hours 300->150; 4 hours 150->75; 6 hours75->37.5; 8 hours 37.5->18.7; 10 hours 18.7->9.4; 12 hours->4.7;
In other words, if you take your pill in the morning, there will notbe any allopurinol in your system when it most needs it, which isabout two to three hours after your big meal. Although the oxypurinolwill still be there, it too will have been reduced to a dosage ofabout half of what you took in the morning.
Therefore, I am suggesting that we need to take our allopurinoleither at dinner or sometime just before dinner by a few hours. Bydoing that, we will have a maximum effect on inhibiting the formationof uric acid, and the difference can be as mush as the difference oftaking 300 mg of allopurinol versus about 75 mg.
I’ll try to say the same thing a different way.
You would probably get as much protection from 100 mg taken before orat dinner time as you get from 300 taken in the morning.