I am in the process of reading as much as I can about gout and alongthe way I will come across things that I believe are important to us.I will post two today.
1) http://www.utah.edu/umed/courses/year2/pharm/study/rx04.pdfSodium Acetyl salycilate, the sodium salt of aspirin, competes withSodium urate for the receptor site that transports uric acid acrossthe membrane in the kidneys and “may exacerbate acute gout attacks.”In other words stay away from aspirin to relieve gout pain. It iscontraindicated and could lead to very serious side effects becauseit can cause coagulation in your renal tubes which can lead to kidneyfailure.
2) Yesterday I posted that high uric acid is associated with heartdisease. Here is one of the references. I found about 12 that suggestit but this seems to be the most comprehensive.
High Uric Acid Linked To Heart Disease DeathsThe Journal of the American Medical Association May 10, 2000;283:2404-2410 http://www.mercola.com/2000/may/14/uric_acid.htm
People who have high levels of uric acid in their blood have anincreased risk of dying from heart disease. The presence of elevateduric acid identifies a sign of greater risk of cardiovascularmortality. The power of that effect — the effect size — is greaterin women than in men and considerably greater in African Americansthan in whites.
Previous studies have suggested that high levels of uric acid in theblood might be linked to heart disease, but the current study is thefirst such study to involve a nationally representative sample ofpeople. In this very large study, uric acid levels were measured innearly 6,000 people aged 25 to 74, who were then followed for anaverage of more than 16 years.
Researchers divided the participants into four groups based on uricacid levels. The lowest group’s level was below 5.4, the secondbetween 5.4-6.1, the third between 6.1- 7 and the fourth was above 7.They found that women who had the most uric acid in their blood werethree times more likely to die from heart disease than those with theleast.
Among men, the risk was 77% higher in men with the highest levelscompared with those with the lowest levels. The risk of dying washigher in blacks than in whites, with black women having the highestincrease in rates, the researchers report.
But in both men and women, the relationship between uric acid andheart-related deaths was only present in people aged 45 and older.People aged 45 to 54 who had high levels of uric acid appeared tohave the highest risk.
Many, but not all, epidemiological studies have suggested that serumuric acid is a risk factor for cardiovascular disease. Increasedserum uric acid levels are linked to obesity, distorted cholesterollevels and high blood pressure (when all three are present this isknown as syndrome X), all of which are also associated with increasedrisk for cardiovascular disease.
Uric acid is a byproduct of the continual process in the body whereold cells are broken down and new ones are formed. Normally, the acidis eliminated from the body in urine. Uric acid is the major productof purine metabolism and is formed from xanthine by the action ofxanthine oxidase.
After menopause, values for women increase. In adults uric acidlevels vary with height, body weight, blood pressure, kidneyfunction, and alcohol intake. Uric acid concentration is influencedby the rate of production on the one hand, and the rate ofelimination on the other. The changing level of serum uric acidconcentration in women at menopause suggests an interaction with sexhormones.
Besides gout, elevated uric acid is related to a variety of otherconditions including increased alcohol consumption, obesity,diabetes, high cholesterol, high blood pressure, kidney disease,heart disease, and water pill use.
More recently, it has been noted that the main reason uric acid iselevated is due to insulin resistance. The increase in serum uricacid levels may be an expression of an insulin-resistant state. Thisis supported by evidence that increased uric acid levels correlatewith decreased insulin-stimulated glucose uptake and increased plasmainsulin response to oral glucose loading.
Original Article
DR. MERCOLA’S COMMENT:
I am enormously impressed with the practical utility of this study,which is why I included so many details of it. The data is taken fromsix thousand people over 16 years. It took quite a while to compilethis association. The reason it is so valuable is that thisinformation is basically free on all chemistry profile tests. Yet,very few people recognize the clinical importance of even a slightlyelevated level.
I have done over 5,000 chemistry profile patient in the last threeyears on patients and am sad to say that I have neglected thisimportant test. Any of my patients who are reading this may want toreview your old tests to find out if in fact your uric acid level isabove 7. This would indicate a much higher risk of heart disease.
Fortunately, the amazing observation is that the same factors thatcause one to have increased weight, cholesterol, blood sugar andblood pressure problems is the same one that causes uric acid toincrease. That factor of course is increased insulin resistance, andregular readers of this newsletter are quite familiar with how tocontrol that. An 1996 study confirmed this quite clearly.
The solution of course is to drastically decrease foods that causesone’s pancreas to make insulin, and that would be all grains, sugars,and underground vegetables (all cereals, rice, breads, bagels, toast,potatoes, chips, pretzels, popcorn, etc.)
The bottom line of this report, backs up with overwhelming statisticsthat a sensible and prudent diet to reduce body weight should be animperative for us. Second and this will require more research, butthere is a secondary connection suggested to pancreatic function, i.einsulin production and uric acid levels. In other words, gout may bea less understood deviation, related to but not the same as, beingassociated with similar metabolic breakdown mechanisms as–DIABETES.My jump to conclusions brain sees this relationship with flashingletters only because of the co-incidence of the two phenomenon andtheir responses in humans but it would make a lot of sense too. Wegout suffferers have a slightly less defective system that adiabetic. The gain in weight relationship is the one that fascinatesme.