Allopurinol
One of the reasons for not starting allopurinol in the firstplace durng an attack is that it is basically impossible to determinewhat kind of gout attack is occurring. The conventional..early stage gout attack is almost alwaysbrought on by a rise in uric acid levels..usually sudden..by whateverreasons.These last a week or two..and go away..or maybenot..sometimes all that goes away is the attack..the white blood cellattack..the deposists just find a home..and get bigger..until..Quiteoften there is a trigger.To a level where the uric acid in theblood..has somehow managed to get into the synovial fluid of the joint(method unknown)or whether the crystals have already started in theblood(not known).This is one of the reasons that blood uric acidlevels are drastically different.1 person may have high levels..nogout..another low levels..gout.It is not so much the blood uric acidlevels but the actual concentration of uric acid in the synovialfluid..and around the joint.Quite often the blood uric acid level atyour arm where the sample is taken has nothing at all to do with theactual concentration of uric acid in the joint.Even the actualconcentration in the joint can be highly misleading..often in chronicgout this is low..especially in the blood because the uric acid isnow in the form of deposits..dense..but not yetcrystalized.Impossible to determine by blood tests.Can’t be seen on x-rays.ONLY when it has crystalized can it be determined by asample..even then..crystals have been seen where there is no goutattack. Starting or staying on allopurinol during an early stage attackwould probabblly be a good idea as it is a powerful drug..capable ofdrastically reducing uric acid levels..fairly quickly..if there areno..or few deposits of uric acid around the joints..this would be agood idea.But then this can not be determined.This is the reason somany Dr.s want people on allopurinol after their first attack..thefirst attack is rarely a case of chronic gout(mine was). The SERIOUS,SERIOUS problem of starting allopurinol during theother type of gout attack..secondary uric acid stage attack is that asudden drop in uric acid levels caused by the allopurinol can casuethese undetected deposits around the joints to go completeleywacko..crystalizing,causing an unbelievable white blood cellattack,basically cutting off circulation and causing instantunbelieveable swelling.These attacks put you in the hospital.There isno way of determing whether there are deposits around thejoints..untill it reaches the severe stage.These deposits canlie..dormant..growing for years..not detectible..ask me aboutit..what causes them is not known. Another gout expert theorizes that changes in uric acidlevels..especially sudden ones.. in the synovial fluid actually stripthe protein from the crystals of uric acid..the white blood cells nowsee the jagged edge of the crystal as a foreign body and attackit.They can’t destroy it and surround it..so many white blood cellsare destroyed that the nucleus of these cells are..waste/dead cellsand this only adds to the uric acid rise..thus the gout attack is nowself perpetuating..sheesh..I’m no bio-mollecular chemist.. Here..you can read my story if you’re bored..you sonn will be HEHE My uric acid level has never been out of the normal range..I havea perfect diet/exercise..always have.This monster struck me withoutwarning March 9 2001..in the balls of my feet..and forefeet..how longis a gout attack?I was on maximum strength colchicne andindomethicine..for?EVERY time I went off the maximum dose..I had amaximum of 12 hours..before another SAVAGE attack..on May 32001..after being in bed 20 hours a day since March.. a specialist,afoot specialist,a rheumatologist.and a g.p. all agreed that thisongoing gout attack..the worst they had ever seen was not going tostop..nor did they know how to stop it..all drugs would do wascontrol it..With only average uric acid levels..and urine testsindicating I was ..not an under excreter..they guessed that if I wenton allopurinol..during the attack..(there really was no other choice)hey just like baking a cake..just give this guy more drugs..(30 Dr.svisits/30 different prescriptions in 6 months)..the only hope Ihad..any reduction in overall blood uric acid levels wouldeventually..hopefully lead to an unfavorable chemical condition forthe uric acid deposits in my feet..and they would leave..it took 11/2 years to get off colchicne/indomethicine.NOTHING else worked.. Yes I have suffered..and done a stupendous amount ofresearch/reading..sad thing is that this disease has so manydifferent facets..all this may help no one..but me. How can this disease be the oldest known to man…goingback..documented 2500 years..also be the one they know the leastabout. Gout..who needs it..ahh..long as I can ski well..and it nevercomes back..SURE..
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