It seems to me that gout is all about enzymes.
Urate crystals form, caused by high acid levels but this causes noproblems on their own. I have been told that Gout sufferers testedbetween flare-ups show crystals in the joints but the crystals haveno effect. Then something (an enzyme?) triggers white cellresponse. This is an ALLERGIC reaction? White cells engulf uratecrystals, assuming that they are bacteria, and start to whack thepseudo bacteria with deadly enzymes. Sharp edged crystals rupturecell walls, enzymes are released, hell fire and damnation let loose.
Body reacts. Kidneys go into overdrive chucking out uric acid (Isuspect that this is why with some people like me the serum uratelevel drops to low levels, confusing the GPs).
This however has NO effect on the pain because there is still anenzyme WAR going on down there one of those nasty little Africanwars, which involve lots of killing and maiming, and mutilated bodiesleft in ditches under the hot sun it is no point screaming youlittle shit because no one will hear you!
In comes colchicine and NSAIDS such as Indomethacin. Body starts tobelch and burp (sorry about that !) and brain floats on cloud ninebut the rebels are more or less disarmed.
However while the attack was taking place and apparently for a timeafter (and this is the bit that I am trying to understand - if ayonehas any views on the subject) the liver goes haywire.
In my case Aspartate Transferase goes to 72 out of its range 15-40,Alanine Transferase goes to 157 out of its range 10-50 and Gamma GTgoes to 59 out of its range 9-40. Shit this looks bad - but whoknows? Look at that Alanine Tranferase, whatever the hell that is,I’m a gonner ! (this is clearly why you should never, ever, let thepatient copy down notes off the pathology report).
Uric acid goes back to what I expect is my normal (bad) level of 5.48.
Ok lets deal with the uric acid. So wait until the enzyme war diesdown in my foot (or at least disappears out of the newspapers), thenslowly introduce Allopurinol.
And what does that do? It inhibits the ENZIME xanthine oxidase.
What is going on with these enzimes???